E88.A

Wasting disease (syndrome) due to underlying condition

FY2027Chapter 4: Endocrine, nutritional and metabolic diseases/E70–E88 Metabolic disorders

BillableComplete code, valid to report

E88.A (also written E88A) is a billable ICD-10-CM diagnosis code for wasting disease (syndrome) due to underlying condition. It is part of the FY2027 code set, effective October 1, 2026. It is one of the 24 codes in category E88 (Other and unspecified metabolic disorders). The Alphabetic Index lists it under 7 entries. Its coding notes include a Code first instruction, a Use additional code instruction, 9 Excludes1 entries and 2 Excludes2 entries.

Code first

If the underlying condition listed here is present and known, sequence it first.

This code
  • underlying condition

Use additional code

Add the listed code as a secondary code, if known.

Inherited from E88 Other and unspecified metabolic disorders
  • codes for associated conditions

Excludes1

Not coded here. The listed conditions generally should not be reported together.

This code
  • cachexia NOS (R64)
  • nutritional marasmus (E41)
Inherited from E88 Other and unspecified metabolic disorders
  • histiocytosis X (chronic) (C96.6)
Also from chapter/block level (6 notes)
Inherited from E70–E88 Metabolic disorders
  • androgen insensitivity syndrome (E34.5-)
  • congenital adrenal hyperplasia (E25.0)
  • hemolytic anemias attributable to enzyme disorders (D55.-)
  • Marfan syndrome (Q87.4-)
  • 5-alpha-reductase deficiency (E29.1)
Inherited from Chapter 4 Endocrine, nutritional and metabolic diseases
  • transitory endocrine and metabolic disorders specific to newborn (P70-P74)

Excludes2

Not included here. Both codes may be reported if the patient has both conditions.

This code
Also from chapter/block level (1 note)
Inherited from E70–E88 Metabolic disorders
  • Ehlers-Danlos syndromes (Q79.6-)

Care settings

How CMS programs treat this code. These are CMS claim edits and list entries, not coverage or eligibility rules.

Hospice: not accepted as primary

Not accepted as the principal diagnosis on a hospice claim (bill types 081x and 082x). The Integrated OCE returns an edit for this code.
Reason: Supplementary or additional code, not allowed as principal diagnosis.

Source: CMS Integrated Outpatient Code Editor (IOCE) v27.3, effective October 1, 2026, edit 113

Inclusion terms

Conditions classified to this code.

This code
  • Cachexia due to underlying condition

Notes

Also from chapter/block level (1 note)
Inherited from Chapter 4 Endocrine, nutritional and metabolic diseases
  • All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.

Alphabetic Index terms

Terms the official Alphabetic Index lists for this code. 7 entries