Alphabetic Index FY2027

D64.81

Anemia due to antineoplastic chemotherapy

FY2027Chapter 3: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism/D60–D64 Aplastic and other anemias and other bone marrow failure syndromes

BillableComplete code, valid to report
Care settingsHome Health Primary · MMTA - Infectious Disease, Neoplasms, and Blood-Forming Diseases

D64.81 (also written D6481) is a billable ICD-10-CM diagnosis code for anemia due to antineoplastic chemotherapy. It is part of the FY2027 code set, effective October 1, 2026. It is one of the 8 codes in category D64 (Other anemias). The Alphabetic Index lists it under 2 entries. Its coding notes include 2 Excludes1 entries and 11 Excludes2 entries.

Guidelines tip

From the FY2027 Official Guidelines. ICD10Ref adds no rules of its own.

When only the anemia is treated, the malignancy is sequenced first for anemia in neoplastic disease. For anemia due to chemotherapy or immunotherapy, the anemia code is first.

Guidelines I.C.2.c.1; I.C.2.c.2Anemia with a malignancy or its treatmentRead the official text

Excludes1

Not coded here. The listed conditions generally should not be reported together.

Inherited from D64 Other anemias
  • refractory anemia (D46.-)
  • refractory anemia with excess blasts in transformation [RAEB T] (C92.0-)

Excludes2

Not included here. Both codes may be reported if the patient has both conditions.

This code
  • anemia in neoplastic disease (D63.0)
  • aplastic anemia due to antineoplastic chemotherapy (D61.1)
Also from chapter/block level (9 notes)
Inherited from Chapter 3 Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
  • autoimmune disease (systemic) NOS (M35.9)
  • certain conditions originating in the perinatal period (P00-P96)
  • complications of pregnancy, childbirth and the puerperium (O00-O9A)
  • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
  • endocrine, nutritional and metabolic diseases (E00-E88)
  • human immunodeficiency virus [HIV] disease (B20)
  • injury, poisoning and certain other consequences of external causes (S00-T88)
  • neoplasms (C00-D49)
  • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)

Care settings

How CMS programs treat this code. These are CMS claim edits and list entries, not coverage or eligibility rules.

Home Health Primary

Accepted as the primary (principal) diagnosis on a home health claim. The Home Health Grouper assigns it to the MMTA - Infectious Disease, Neoplasms, and Blood-Forming Diseases clinical group.

Source: CMS Home Health Grouper Software v07.2.26, effective October 1, 2026

Inclusion terms

Conditions classified to this code.

This code
  • Antineoplastic chemotherapy induced anemia

Alphabetic Index terms

Terms the official Alphabetic Index lists for this code. 2 entries