M35.9

Systemic involvement of connective tissue, unspecified

FY2027Chapter 13: Diseases of the musculoskeletal system and connective tissue/M30–M36 Systemic connective tissue disorders

BillableComplete code, valid to report

M35.9 (also written M359) is a billable ICD-10-CM diagnosis code for systemic involvement of connective tissue, unspecified. It is part of the FY2027 code set, effective October 1, 2026. It is one of the 23 codes in category M35 (Other systemic involvement of connective tissue). The Alphabetic Index lists it under 12 entries. Its coding notes include 2 Excludes1 entries and 10 Excludes2 entries.

Excludes1

Not coded here. The listed conditions generally should not be reported together.

Inherited from M35 Other systemic involvement of connective tissue
  • reactive perforating collagenosis (L87.1)
Also from chapter/block level (1 note)
Inherited from M30–M36 Systemic connective tissue disorders
  • autoimmune disease, single organ or single cell-type -code to relevant condition category

Excludes2

Not included here. Both codes may be reported if the patient has both conditions.

Also from chapter/block level (10 notes)
Inherited from Chapter 13 Diseases of the musculoskeletal system and connective tissue
  • arthropathic psoriasis (L40.5-)
  • certain conditions originating in the perinatal period (P04-P96)
  • certain infectious and parasitic diseases (A00-B99)
  • compartment syndrome (traumatic) (T79.A-)
  • complications of pregnancy, childbirth and the puerperium (O00-O9A)
  • congenital malformations, deformations, and chromosomal abnormalities (Q00-Q99)
  • endocrine, nutritional and metabolic diseases (E00-E88)
  • injury, poisoning and certain other consequences of external causes (S00-T88)
  • neoplasms (C00-D49)
  • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)

Includes

Further defines or gives examples of the content of the category.

Also from chapter/block level (4 notes)
Inherited from M30–M36 Systemic connective tissue disorders
  • autoimmune disease NOS
  • collagen (vascular) disease NOS
  • systemic autoimmune disease
  • systemic collagen (vascular) disease

Inclusion terms

Conditions classified to this code.

This code
  • Autoimmune disease (systemic) NOS
  • Collagen (vascular) disease NOS

Notes

Also from chapter/block level (1 note)
Inherited from Chapter 13 Diseases of the musculoskeletal system and connective tissue
  • Use an external cause code following the code for the musculoskeletal condition, if applicable, to identify the cause of the musculoskeletal condition

Alphabetic Index terms

Terms the official Alphabetic Index lists for this code. 12 entries