D59.5
Paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli]
D59.5 (also written D595) is a billable ICD-10-CM diagnosis code for paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli]. It is part of the FY2027 code set, effective October 1, 2026. It is one of the 16 codes in category D59 (Acquired hemolytic anemia). The Alphabetic Index lists it under 5 entries. Its coding notes include 1 Excludes1 entry and 9 Excludes2 entries.
Excludes1
Not coded here. The listed conditions generally should not be reported together.
- hemoglobinuria NOS (R82.3)
Excludes2
Not included here. Both codes may be reported if the patient has both conditions.
Also from chapter/block level (9 notes)
- autoimmune disease (systemic) NOS (M35.9)
- certain conditions originating in the perinatal period (P00-P96)
- complications of pregnancy, childbirth and the puerperium (O00-O9A)
- congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
- endocrine, nutritional and metabolic diseases (E00-E88)
- human immunodeficiency virus [HIV] disease (B20)
- injury, poisoning and certain other consequences of external causes (S00-T88)
- neoplasms (C00-D49)
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
Care settings
How CMS programs treat this code. These are CMS claim edits and list entries, not coverage or eligibility rules.
Home Health Primary
Accepted as the primary (principal) diagnosis on a home health claim. The Home Health Grouper assigns it to the MMTA - Infectious Disease, Neoplasms, and Blood-Forming Diseases clinical group.
Source: CMS Home Health Grouper Software v07.2.26, effective October 1, 2026Alphabetic Index terms
Terms the official Alphabetic Index lists for this code. 5 entries