D59.4
Other nonautoimmune hemolytic anemias
D59.4 (also written D594) is a billable ICD-10-CM diagnosis code for other nonautoimmune hemolytic anemias. It is part of the FY2027 code set, effective October 1, 2026. It is one of the 16 codes in category D59 (Acquired hemolytic anemia). The Alphabetic Index lists it under 13 entries. Its coding notes include 9 Excludes2 entries.
Excludes2
Not included here. Both codes may be reported if the patient has both conditions.
Also from chapter/block level (9 notes)
- autoimmune disease (systemic) NOS (M35.9)
- certain conditions originating in the perinatal period (P00-P96)
- complications of pregnancy, childbirth and the puerperium (O00-O9A)
- congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
- endocrine, nutritional and metabolic diseases (E00-E88)
- human immunodeficiency virus [HIV] disease (B20)
- injury, poisoning and certain other consequences of external causes (S00-T88)
- neoplasms (C00-D49)
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
Care settings
How CMS programs treat this code. These are CMS claim edits and list entries, not coverage or eligibility rules.
Home Health Primary
Accepted as the primary (principal) diagnosis on a home health claim. The Home Health Grouper assigns it to the MMTA - Infectious Disease, Neoplasms, and Blood-Forming Diseases clinical group.
Source: CMS Home Health Grouper Software v07.2.26, effective October 1, 2026Hospital CC
Counts as a complication or comorbidity (CC) when reported as a secondary diagnosis on an inpatient claim. It does not count when the principal diagnosis is one of the 110 codes in its exclusion list. Some MS-DRGs also ignore a CC or MCC that defines the DRG.
Source: CMS MS-DRG Definitions Manual v44, effective October 1, 2026, Appendix CInclusion terms
Conditions classified to this code.
- Mechanical hemolytic anemia
- Microangiopathic hemolytic anemia
- Toxic hemolytic anemia
Alphabetic Index terms
Terms the official Alphabetic Index lists for this code. 13 entries
- Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound), hemolytic, acquired, infectious
- Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound), hemolytic, acquired, toxic
- Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound), hemolytic, due to, cardiac conditions
- Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound), hemolytic, due to, presence of shunt or other internal prosthetic device
- Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound), hemolytic, mechanical
- Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound), hemolytic, microangiopathic
- Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound), hemolytic, nonautoimmune
- Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound), hemolytic, secondary
- Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound), hemolytic, symptomatic
- Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound), hemolytic, toxic
- Disease, diseased, nonautoimmune hemolytic
- Nonautoimmune hemolytic anemia