D57
Sickle-cell disorders
D57 is a non-billable ICD-10-CM code category for sickle-cell disorders. Report a more specific code from it instead. It is part of the FY2027 code set, effective October 1, 2026. The more specific codes under it are D57.0 Hb-SS disease with crisis, D57.1 Sickle-cell disease without crisis, D57.2 Sickle-cell/Hb-C disease, D57.3 Sickle-cell trait and 2 more. Its coding notes include a Use additional code instruction, 1 Excludes1 entry and 9 Excludes2 entries.
Use additional code
Add the listed code as a secondary code, if known.
- code for any associated fever (R50.81)
Excludes1
Not coded here. The listed conditions generally should not be reported together.
- other hemoglobinopathies (D58.-)
Excludes2
Not included here. Both codes may be reported if the patient has both conditions.
Also from chapter/block level (9 notes)
- autoimmune disease (systemic) NOS (M35.9)
- certain conditions originating in the perinatal period (P00-P96)
- complications of pregnancy, childbirth and the puerperium (O00-O9A)
- congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
- endocrine, nutritional and metabolic diseases (E00-E88)
- human immunodeficiency virus [HIV] disease (B20)
- injury, poisoning and certain other consequences of external causes (S00-T88)
- neoplasms (C00-D49)
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
Alphabetic Index terms
Terms the official Alphabetic Index lists for this code. 7 entries
- Arthropathy, gouty, in (due to), sickle-cell disorders
- Disorder (of), glomerular (in), sickle-cell disorders
- Glomerulonephritis, in (due to), sickle-cell disorders
- Nephropathy, sickle-cell
- Retinopathy (background), in (due to), sickle-cell disorders, nonproliferative
- Retinopathy (background), in (due to), sickle-cell disorders, proliferative
- Retinopathy (background), proliferative NEC, sickle-cell