D57.4
Sickle-cell thalassemia
D57.4 is a non-billable ICD-10-CM code header for sickle-cell thalassemia. Report a more specific code from it instead. It is part of the FY2027 code set, effective October 1, 2026. The more specific codes under it are D57.40 Sickle-cell thalassemia without crisis; D57.41 Sickle-cell thalassemia, unspecified, with crisis; D57.42 Sickle-cell thalassemia beta zero without crisis; D57.43 Sickle-cell thalassemia beta zero with crisis and 2 more. Its coding notes include a Use additional code instruction, 1 Excludes1 entry and 9 Excludes2 entries.
Use additional code
Add the listed code as a secondary code, if known.
Excludes1
Not coded here. The listed conditions generally should not be reported together.
Excludes2
Not included here. Both codes may be reported if the patient has both conditions.
Also from chapter/block level (9 notes)
- autoimmune disease (systemic) NOS (M35.9)
- certain conditions originating in the perinatal period (P00-P96)
- complications of pregnancy, childbirth and the puerperium (O00-O9A)
- congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
- endocrine, nutritional and metabolic diseases (E00-E88)
- human immunodeficiency virus [HIV] disease (B20)
- injury, poisoning and certain other consequences of external causes (S00-T88)
- neoplasms (C00-D49)
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
Inclusion terms
Conditions classified to this code.
- Sickle-cell beta thalassemia
- Thalassemia Hb-S disease
More specific codes under D57.4 6
- D57.40Sickle-cell thalassemia without crisisBillable
- D57.41Sickle-cell thalassemia, unspecified, with crisisHeader
- D57.42Sickle-cell thalassemia beta zero without crisisBillable
- D57.43Sickle-cell thalassemia beta zero with crisisHeader
- D57.44Sickle-cell thalassemia beta plus without crisisBillable
- D57.45Sickle-cell thalassemia beta plus with crisisHeader