Alphabetic Index FY2027

D57.45

Sickle-cell thalassemia beta plus with crisis

FY2027Chapter 3: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism/D55–D59 Hemolytic anemias

Non-billable headerNot valid on its own. Use one of the more specific codes under it.

D57.45 is a non-billable ICD-10-CM code header for sickle-cell thalassemia beta plus with crisis. Report a more specific code from it instead. It is part of the FY2027 code set, effective October 1, 2026. The more specific codes under it are D57.451 Sickle-cell thalassemia beta plus with acute chest syndrome, D57.452 Sickle-cell thalassemia beta plus with splenic sequestration, D57.453 Sickle-cell thalassemia beta plus with cerebral vascular involvement, D57.454 Sickle-cell thalassemia beta plus with dactylitis and 2 more. Its coding notes include a Use additional code instruction, 1 Excludes1 entry and 9 Excludes2 entries.

Use additional code

Add the listed code as a secondary code, if known.

Inherited from D57 Sickle-cell disorders
  • code for any associated fever (R50.81)

Excludes1

Not coded here. The listed conditions generally should not be reported together.

Inherited from D57 Sickle-cell disorders
  • other hemoglobinopathies (D58.-)

Excludes2

Not included here. Both codes may be reported if the patient has both conditions.

Also from chapter/block level (9 notes)
Inherited from Chapter 3 Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
  • autoimmune disease (systemic) NOS (M35.9)
  • certain conditions originating in the perinatal period (P00-P96)
  • complications of pregnancy, childbirth and the puerperium (O00-O9A)
  • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
  • endocrine, nutritional and metabolic diseases (E00-E88)
  • human immunodeficiency virus [HIV] disease (B20)
  • injury, poisoning and certain other consequences of external causes (S00-T88)
  • neoplasms (C00-D49)
  • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)

Inclusion terms

Conditions classified to this code.

This code
  • HbS-beta plus with crisis
  • Sickle-cell beta plus with crisis

More specific codes under D57.45 6