D82.1
Di George's syndrome
D82.1 (also written D821) is a billable ICD-10-CM diagnosis code for di George's syndrome. It is part of the FY2027 code set, effective October 1, 2026. It is one of the 7 codes in category D82 (Immunodeficiency associated with other major defects). The Alphabetic Index lists it under 12 entries. Its coding notes include 3 Excludes1 entries and 10 Excludes2 entries.
Excludes1
Not coded here. The listed conditions generally should not be reported together.
Excludes2
Not included here. Both codes may be reported if the patient has both conditions.
Also from chapter/block level (10 notes)
- human immunodeficiency virus [HIV] disease (B20)
- autoimmune disease (systemic) NOS (M35.9)
- certain conditions originating in the perinatal period (P00-P96)
- complications of pregnancy, childbirth and the puerperium (O00-O9A)
- congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
- endocrine, nutritional and metabolic diseases (E00-E88)
- human immunodeficiency virus [HIV] disease (B20)
- injury, poisoning and certain other consequences of external causes (S00-T88)
- neoplasms (C00-D49)
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
Care settings
How CMS programs treat this code. These are CMS claim edits and list entries, not coverage or eligibility rules.
Home Health Primary
Accepted as the primary (principal) diagnosis on a home health claim. The Home Health Grouper assigns it to the MMTA - Infectious Disease, Neoplasms, and Blood-Forming Diseases clinical group.
Source: CMS Home Health Grouper Software v07.2.26, effective October 1, 2026Hospital CC
Counts as a complication or comorbidity (CC) when reported as a secondary diagnosis on an inpatient claim. It does not count when the principal diagnosis is one of the 44 codes in its exclusion list. Some MS-DRGs also ignore a CC or MCC that defines the DRG.
Source: CMS MS-DRG Definitions Manual v44, effective October 1, 2026, Appendix CIncludes
Further defines or gives examples of the content of the category.
Also from chapter/block level (3 notes)
- defects in the complement system
- immunodeficiency disorders, except human immunodeficiency virus [HIV] disease
- sarcoidosis
Inclusion terms
Conditions classified to this code.
- Pharyngeal pouch syndrome
- Thymic alymphoplasia
- Thymic aplasia or hypoplasia with immunodeficiency
Alphabetic Index terms
Terms the official Alphabetic Index lists for this code. 12 entries
- Alymphocytosis, thymic (with immunodeficiency)
- Alymphoplasia, thymic
- Aplasia, parathyroid-thymic
- Aplasia, thymic, with immunodeficiency
- Di George's syndrome
- DiGeorge's syndrome (thymic hypoplasia)
- Dysplasia, thymic, with immunodeficiency
- Hypoplasia, hypoplastic, thymic, with immunodeficiency
- Hypoplasia, hypoplastic, thymus (gland), with immunodeficiency
- Pharyngeal pouch syndrome
- Syndrome, di George's
- Syndrome, pharyngeal pouch