D61.01
Constitutional (pure) red blood cell aplasia
D61.01 (also written D6101) is a billable ICD-10-CM diagnosis code for constitutional (pure) red blood cell aplasia. It is part of the FY2027 code set, effective October 1, 2026. It is one of the 13 codes in category D61 (Other aplastic anemias and other bone marrow failure syndromes). The Alphabetic Index lists it under 24 entries. Its coding notes include 1 Excludes1 entry and 10 Excludes2 entries.
Excludes1
Not coded here. The listed conditions generally should not be reported together.
- acquired red cell aplasia (D60.9)
Excludes2
Not included here. Both codes may be reported if the patient has both conditions.
- neutropenia (D70.-)
Also from chapter/block level (9 notes)
- autoimmune disease (systemic) NOS (M35.9)
- certain conditions originating in the perinatal period (P00-P96)
- complications of pregnancy, childbirth and the puerperium (O00-O9A)
- congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
- endocrine, nutritional and metabolic diseases (E00-E88)
- human immunodeficiency virus [HIV] disease (B20)
- injury, poisoning and certain other consequences of external causes (S00-T88)
- neoplasms (C00-D49)
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
Care settings
How CMS programs treat this code. These are CMS claim edits and list entries, not coverage or eligibility rules.
Home Health Primary
Accepted as the primary (principal) diagnosis on a home health claim. The Home Health Grouper assigns it to the MMTA - Infectious Disease, Neoplasms, and Blood-Forming Diseases clinical group.
Source: CMS Home Health Grouper Software v07.2.26, effective October 1, 2026Hospital CC
Counts as a complication or comorbidity (CC) when reported as a secondary diagnosis on an inpatient claim. It does not count when the principal diagnosis is one of the 98 codes in its exclusion list. Some MS-DRGs also ignore a CC or MCC that defines the DRG.
Source: CMS MS-DRG Definitions Manual v44, effective October 1, 2026, Appendix CInclusion terms
Conditions classified to this code.
- Blackfan-Diamond syndrome
- Congenital (pure) red cell aplasia
- Familial hypoplastic anemia
- Primary (pure) red cell aplasia
- Red cell (pure) aplasia of infants
Alphabetic Index terms
Terms the official Alphabetic Index lists for this code. 24 entries
- Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound), aplastic, red cell (pure), congenital
- Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound), Diamond-Blackfan (congenital hypoplastic)
- Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound), hypoplasia, red blood cells, congenital or familial
- Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound), hypoplastic (idiopathic), congenital or familial (of childhood)
- Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound), Joseph-Diamond-Blackfan (congenital hypoplastic)
- Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound), pure red cell, congenital
- Aplasia, bone marrow (myeloid), congenital
- Aplasia, congenital pure red cell
- Aplasia, erythrocyte congenital
- Aplasia, red cell (with thymoma), congenital
- Aplasia, red cell (with thymoma), constitutional
- Aplasia, red cell (with thymoma), hereditary
Show 12 more
- Aplasia, red cell (with thymoma), of infants
- Aplasia, red cell (with thymoma), primary
- Aplasia, red cell (with thymoma), pure
- Blackfan-Diamond anemia or syndrome (congenital hypoplastic anemia)
- Diamond-Blackfan anemia (congenital hypoplastic)
- Erythroblastopenia, congenital
- Hypoplasia, hypoplastic, erythroid, congenital
- Joseph-Diamond-Blackfan anemia (congenital hypoplastic)
- Kaznelson's syndrome (congenital hypoplastic anemia)
- Syndrome, Blackfan-Diamond
- Syndrome, Diamond-Blackfan
- Syndrome, Joseph-Diamond-Blackfan