M31.11
Hematopoietic stem cell transplantation-associated thrombotic microangiopathy [HSCT-TMA]
M31.11 (also written M3111) is a billable ICD-10-CM diagnosis code for hematopoietic stem cell transplantation-associated thrombotic microangiopathy [HSCT-TMA]. It is part of the FY2027 code set, effective October 1, 2026. It is one of the 13 codes in category M31 (Other necrotizing vasculopathies). The Alphabetic Index lists it under 2 entries. Its coding notes include a Code first instruction, a Use additional code instruction, 1 Excludes1 entry and 10 Excludes2 entries.
Code first
If the underlying condition listed here is present and known, sequence it first.
Use additional code
Add the listed code as a secondary code, if known.
- code to identify specific organ dysfunction, such as:
- acute kidney failure (N17.-)
- acute respiratory distress syndrome (J80)
- capillary leak syndrome (I78.8)
- diffuse alveolar hemorrhage (R04.89)
- encephalopathy (metabolic) (septic) (G93.41)
- fluid overload, unspecified (E87.70)
- graft versus host disease (D89.81-)
- hemolytic uremic syndrome (D59.3-)
- hepatic failure (K72.-)
- hepatic veno-occlusive disease (K76.5)
- idiopathic interstitial pneumonia (J84.11-)
- sinusoidal obstruction syndrome (K76.5)
Excludes1
Not coded here. The listed conditions generally should not be reported together.
Also from chapter/block level (1 note)
- autoimmune disease, single organ or single cell-type -code to relevant condition category
Excludes2
Not included here. Both codes may be reported if the patient has both conditions.
Also from chapter/block level (10 notes)
- arthropathic psoriasis (L40.5-)
- certain conditions originating in the perinatal period (P04-P96)
- certain infectious and parasitic diseases (A00-B99)
- compartment syndrome (traumatic) (T79.A-)
- complications of pregnancy, childbirth and the puerperium (O00-O9A)
- congenital malformations, deformations, and chromosomal abnormalities (Q00-Q99)
- endocrine, nutritional and metabolic diseases (E00-E88)
- injury, poisoning and certain other consequences of external causes (S00-T88)
- neoplasms (C00-D49)
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
Care settings
How CMS programs treat this code. These are CMS claim edits and list entries, not coverage or eligibility rules.
Hospital MCC
Counts as a major complication or comorbidity (MCC) when reported as a secondary diagnosis on an inpatient claim. It does not count when the principal diagnosis is one of the 25 codes in its exclusion list. Some MS-DRGs also ignore a CC or MCC that defines the DRG.
Source: CMS MS-DRG Definitions Manual v44, effective October 1, 2026, Appendix CIncludes
Further defines or gives examples of the content of the category.
Also from chapter/block level (4 notes)
- autoimmune disease NOS
- collagen (vascular) disease NOS
- systemic autoimmune disease
- systemic collagen (vascular) disease
Inclusion terms
Conditions classified to this code.
- Transplant-associated thrombotic microangiopathy [TA-TMA]
Notes
Also from chapter/block level (1 note)
- Use an external cause code following the code for the musculoskeletal condition, if applicable, to identify the cause of the musculoskeletal condition
Alphabetic Index terms
Terms the official Alphabetic Index lists for this code. 2 entries