E23.0
Hypopituitarism
E23.0 (also written E230) is a billable ICD-10-CM diagnosis code for hypopituitarism. It is part of the FY2027 code set, effective October 1, 2026. It is one of the 6 codes in category E23 (Hypofunction and other disorders of the pituitary gland). The Alphabetic Index lists it under 44 entries. Its coding notes include a Use additional code instruction and 5 Excludes1 entries.
Use additional code
Add the listed code as a secondary code, if known.
- code, if applicable, for associated cachexia (E88.A)
Excludes1
Not coded here. The listed conditions generally should not be reported together.
Care settings
How CMS programs treat this code. These are CMS claim edits and list entries, not coverage or eligibility rules.
Home Health Primary
Accepted as the primary (principal) diagnosis on a home health claim. The Home Health Grouper assigns it to the MMTA - Endocrine clinical group.
Source: CMS Home Health Grouper Software v07.2.26, effective October 1, 2026IRF 60% Rule
On the CMS list of diagnoses used to determine presumptive compliance with the IRF 60 percent rule.
Source: CMS IRF Presumptive Compliance-3, FY 2027 IRF PPS final rule files, effective for discharges on or after October 1, 2026Hospital CC
Counts as a complication or comorbidity (CC) when reported as a secondary diagnosis on an inpatient claim. It does not count when the principal diagnosis is one of the 21 codes in its exclusion list. Some MS-DRGs also ignore a CC or MCC that defines the DRG.
Source: CMS MS-DRG Definitions Manual v44, effective October 1, 2026, Appendix CIncludes
Further defines or gives examples of the content of the category.
- the listed conditions whether the disorder is in the pituitary or the hypothalamus
Inclusion terms
Conditions classified to this code.
- Fertile eunuch syndrome
- Hypogonadotropic hypogonadism
- Idiopathic growth hormone deficiency
- Isolated deficiency of gonadotropin
- Isolated deficiency of growth hormone
- Isolated deficiency of pituitary hormone
- Kallmann's syndrome
- Lorain-Levi short stature
- Necrosis of pituitary gland (postpartum)
- Panhypopituitarism
- Pituitary cachexia
- Pituitary insufficiency NOS
- Pituitary short stature
- Sheehan's syndrome
- Simmonds' disease
Notes
Also from chapter/block level (1 note)
- All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
Alphabetic Index terms
Terms the official Alphabetic Index lists for this code. 44 entries
- Ahumada-del Castillo syndrome
- Brissaud's, infantilism or dwarfism
- Cachexia, hypophyseal
- Cachexia, hypopituitary
- Cachexia, pituitary
- Cachexia, Simmonds'
- Decrease (d), function, ovary in hypopituitarism
- Decrease (d), function, pituitary (gland) (anterior) (lobe)
- Decrease (d), function, pituitary (gland) (anterior) (lobe), posterior (lobe)
- Deficiency, deficient, gonadotropin (isolated)
- Deficiency, deficient, growth hormone (idiopathic) (isolated)
- Deficiency, deficient, hormone, anterior pituitary (partial) NEC
Show 32 more
- Deficiency, deficient, hormone, anterior pituitary (partial) NEC, growth
- Deficiency, deficient, hormone, growth (isolated)
- Deficiency, deficient, hormone, pituitary
- Deficiency, deficient, pituitary hormone (isolated)
- Dwarfism, hypophyseal
- Dwarfism, Lorain (-Levi) type
- Dwarfism, pituitary
- Eunuchoidism, hypogonadotropic
- Fertile eunuch syndrome
- Hypoadrenocorticism, pituitary
- Hypofunction, pituitary (gland) (anterior)
- Hypogonadism, hypogonadotropic
- Hypogonadism, pituitary
- Hypophyseal, hypophysis, dwarfism
- Hypopituitarism (juvenile)
- Hyposecretion, ACTH
- Infancy, infantile, infantilism, Lorain
- Infancy, infantile, infantilism, pituitary
- Infertility, female, associated with, pituitary-hypothalamic origin
- Insufficiency, insufficient, pituitary
- Kallmann's syndrome
- Lorain (-Levi) short stature syndrome
- Myopathy, in (due to), hypopituitarism
- Necrosis, necrotic (ischemic), pituitary (gland)
- Panhypopituitarism
- Panhypopituitarism, prepubertal
- Sheehan's disease or syndrome
- Simmonds' cachexia or disease
- Syndrome, fertile eunuch
- Syndrome, hypopituitarism
- Syndrome, infantilism (pituitary)
- Syndrome, postpartum panhypopituitary (Sheehan)