E22

Hyperfunction of pituitary gland

FY2027Chapter 4: Endocrine, nutritional and metabolic diseases/E20–E35 Disorders of other endocrine glands

Non-billable headerNot valid on its own. Use one of the more specific codes under it.

E22 is a non-billable ICD-10-CM code category for hyperfunction of pituitary gland. Report a more specific code from it instead. It is part of the FY2027 code set, effective October 1, 2026. The more specific codes under it are E22.0 Acromegaly and pituitary gigantism, E22.1 Hyperprolactinemia, E22.2 Syndrome of inappropriate secretion of antidiuretic hormone, E22.8 Other hyperfunction of pituitary gland and 1 more. Its coding notes include 8 Excludes1 entries.

Excludes1

Not coded here. The listed conditions generally should not be reported together.

This code
  • Cushing's syndrome (E24.-)
  • Nelson's syndrome (E24.1)
  • overproduction of ACTH not associated with Cushing's disease (E27.0)
  • overproduction of pituitary ACTH (E24.0)
  • overproduction of thyroid-stimulating hormone (E05.8-)
Also from chapter/block level (3 notes)
Inherited from E20–E35 Disorders of other endocrine glands
Inherited from Chapter 4 Endocrine, nutritional and metabolic diseases
  • transitory endocrine and metabolic disorders specific to newborn (P70-P74)

Notes

Also from chapter/block level (1 note)
Inherited from Chapter 4 Endocrine, nutritional and metabolic diseases
  • All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.

More specific codes under E22 5