E22.9
Hyperfunction of pituitary gland, unspecified
E22.9 (also written E229) is a billable ICD-10-CM diagnosis code for hyperfunction of pituitary gland, unspecified. It is part of the FY2027 code set, effective October 1, 2026. It is one of the 5 codes in category E22 (Hyperfunction of pituitary gland). The Alphabetic Index lists it under 4 entries. Its coding notes include 8 Excludes1 entries.
Excludes1
Not coded here. The listed conditions generally should not be reported together.
Care settings
How CMS programs treat this code. These are CMS claim edits and list entries, not coverage or eligibility rules.
Hospital CC
Counts as a complication or comorbidity (CC) when reported as a secondary diagnosis on an inpatient claim. It does not count when the principal diagnosis is one of the 4 codes in its exclusion list. Some MS-DRGs also ignore a CC or MCC that defines the DRG.
Source: CMS MS-DRG Definitions Manual v44, effective October 1, 2026, Appendix CNotes
Also from chapter/block level (1 note)
- All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
Alphabetic Index terms
Terms the official Alphabetic Index lists for this code. 4 entries