E22.0
Acromegaly and pituitary gigantism
E22.0 (also written E220) is a billable ICD-10-CM diagnosis code for acromegaly and pituitary gigantism. It is part of the FY2027 code set, effective October 1, 2026. It is one of the 5 codes in category E22 (Hyperfunction of pituitary gland). The Alphabetic Index lists it under 20 entries. Its coding notes include 11 Excludes1 entries.
Excludes1
Not coded here. The listed conditions generally should not be reported together.
Care settings
How CMS programs treat this code. These are CMS claim edits and list entries, not coverage or eligibility rules.
Home Health Primary
Accepted as the primary (principal) diagnosis on a home health claim. The Home Health Grouper assigns it to the MMTA - Endocrine clinical group.
Source: CMS Home Health Grouper Software v07.2.26, effective October 1, 2026Inclusion terms
Conditions classified to this code.
- Overproduction of growth hormone
Notes
Also from chapter/block level (1 note)
- All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
Alphabetic Index terms
Terms the official Alphabetic Index lists for this code. 20 entries
- Acromegaly, acromegalia
- Arthritis, arthritic (acute) (chronic) (nonpyogenic) (subacute), due to or associated with, acromegaly
- Arthritis, arthritic (acute) (chronic) (nonpyogenic) (subacute), in (due to), acromegaly
- Arthropathy, in (due to), acromegaly
- Erdheim's syndrome (acromegalic macrospondylitis)
- Gigantism (cerebral) (hypophyseal) (pituitary)
- Hypersecretion, hormone (s), growth
- Hypophyseal, hypophysis, gigantism
- Launois' syndrome (pituitary gigantism)
- Macrospondylitis , acromegalic
- Marie's, disease or syndrome (acromegaly)
- Overproduction, growth hormone