Alphabetic Index FY2027

D57.818

Other sickle-cell disorders with crisis with other specified complication

FY2027Chapter 3: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism/D55–D59 Hemolytic anemias

BillableComplete code, valid to report
Care settingsHome Health Primary · MMTA - Infectious Disease, Neoplasms, and Blood-Forming DiseasesHospital MCC

D57.818 (also written D57818) is a billable ICD-10-CM diagnosis code for other sickle-cell disorders with crisis with other specified complication. It is part of the FY2027 code set, effective October 1, 2026. It is one of the 43 codes in category D57 (Sickle-cell disorders). The Alphabetic Index lists it under 8 entries. Its coding notes include a Use additional code instruction, 1 Excludes1 entry and 9 Excludes2 entries.

Use additional code

Add the listed code as a secondary code, if known.

This code
  • code to identify complications, such as:
Inherited from D57 Sickle-cell disorders
  • code for any associated fever (R50.81)

Excludes1

Not coded here. The listed conditions generally should not be reported together.

Inherited from D57 Sickle-cell disorders
  • other hemoglobinopathies (D58.-)

Excludes2

Not included here. Both codes may be reported if the patient has both conditions.

Also from chapter/block level (9 notes)
Inherited from Chapter 3 Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
  • autoimmune disease (systemic) NOS (M35.9)
  • certain conditions originating in the perinatal period (P00-P96)
  • complications of pregnancy, childbirth and the puerperium (O00-O9A)
  • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
  • endocrine, nutritional and metabolic diseases (E00-E88)
  • human immunodeficiency virus [HIV] disease (B20)
  • injury, poisoning and certain other consequences of external causes (S00-T88)
  • neoplasms (C00-D49)
  • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)

Care settings

How CMS programs treat this code. These are CMS claim edits and list entries, not coverage or eligibility rules.

Home Health Primary

Accepted as the primary (principal) diagnosis on a home health claim. The Home Health Grouper assigns it to the MMTA - Infectious Disease, Neoplasms, and Blood-Forming Diseases clinical group.

Source: CMS Home Health Grouper Software v07.2.26, effective October 1, 2026

Hospital MCC

Counts as a major complication or comorbidity (MCC) when reported as a secondary diagnosis on an inpatient claim. It does not count when the principal diagnosis is one of the 48 codes in its exclusion list. Some MS-DRGs also ignore a CC or MCC that defines the DRG.

Source: CMS MS-DRG Definitions Manual v44, effective October 1, 2026, Appendix C

Alphabetic Index terms

Terms the official Alphabetic Index lists for this code. 8 entries