Alphabetic Index FY2027

A41.4

Sepsis due to anaerobes

FY2027Chapter 1: Certain infectious and parasitic diseases/A30–A49 Other bacterial diseases

BillableComplete code, valid to report
Care settingsHome Health Primary · MMTA - Infectious Disease, Neoplasms, and Blood-Forming DiseasesHospital MCC

A41.4 (also written A414) is a billable ICD-10-CM diagnosis code for sepsis due to anaerobes. It is part of the FY2027 code set, effective October 1, 2026. It is one of the 15 codes in category A41 (Other sepsis). The Alphabetic Index lists it under 6 entries. Its coding notes include a Code first instruction, a Use additional code instruction, 5 Excludes1 entries and 18 Excludes2 entries.

Guidelines tip

From the FY2027 Official Guidelines. ICD10Ref adds no rules of its own.

Sepsis is coded to the underlying systemic infection, with A41.9 as the default. Urosepsis has no default code and the provider must be queried. R65.2 needs documented severe sepsis or associated organ dysfunction.

Guidelines I.C.1.d.1.aSepsis, severe sepsis and urosepsisRead the official text

Code first

If the underlying condition listed here is present and known, sequence it first.

Inherited from A41 Other sepsis

Use additional code

Add the listed code as a secondary code, if known.

Also from chapter/block level (1 note)
Inherited from Chapter 1 Certain infectious and parasitic diseases
  • code to identify resistance to antimicrobial drugs (Z16.-)

Excludes1

Not coded here. The listed conditions generally should not be reported together.

This code
Inherited from A41 Other sepsis

Excludes2

Not included here. Both codes may be reported if the patient has both conditions.

Inherited from A41 Other sepsis
  • sepsis (due to) (in) actinomycotic (A42.7)
  • sepsis (due to) (in) anthrax (A22.7)
  • sepsis (due to) (in) candidal (B37.7)
  • sepsis (due to) (in) Erysipelothrix (A26.7)
  • sepsis (due to) (in) extraintestinal yersiniosis (A28.2)
  • sepsis (due to) (in) gonococcal (A54.86)
  • sepsis (due to) (in) herpesviral (B00.7)
  • sepsis (due to) (in) listerial (A32.7)
  • sepsis (due to) (in) melioidosis (A24.1)
  • sepsis (due to) (in) meningococcal (A39.2-A39.4)
  • sepsis (due to) (in) plague (A20.7)
  • sepsis (due to) (in) tularemia (A21.7)
  • toxic shock syndrome (A48.3)
Also from chapter/block level (5 notes)
Inherited from Chapter 1 Certain infectious and parasitic diseases
  • carrier or suspected carrier of infectious disease (Z22.-)
  • certain localized infections - see body system-related chapters
  • infectious and parasitic diseases complicating pregnancy, childbirth and the puerperium (O98.-)
  • infectious and parasitic diseases specific to the perinatal period (P35-P39)
  • influenza and other acute respiratory infections (J00-J22)

Care settings

How CMS programs treat this code. These are CMS claim edits and list entries, not coverage or eligibility rules.

Home Health Primary

Accepted as the primary (principal) diagnosis on a home health claim. The Home Health Grouper assigns it to the MMTA - Infectious Disease, Neoplasms, and Blood-Forming Diseases clinical group.

Source: CMS Home Health Grouper Software v07.2.26, effective October 1, 2026

Hospital MCC

Counts as a major complication or comorbidity (MCC) when reported as a secondary diagnosis on an inpatient claim. It does not count when the principal diagnosis is one of the 46 codes in its exclusion list. Some MS-DRGs also ignore a CC or MCC that defines the DRG.

Source: CMS MS-DRG Definitions Manual v44, effective October 1, 2026, Appendix C

Includes

Further defines or gives examples of the content of the category.

Also from chapter/block level (1 note)
Inherited from Chapter 1 Certain infectious and parasitic diseases
  • diseases generally recognized as communicable or transmissible

Alphabetic Index terms

Terms the official Alphabetic Index lists for this code. 6 entries