N16
Renal tubulo-interstitial disorders in diseases classified elsewhere
N16 is a billable ICD-10-CM diagnosis code for renal tubulo-interstitial disorders in diseases classified elsewhere. It is part of the FY2027 code set, effective October 1, 2026. The Alphabetic Index lists it under 22 entries. Its coding notes include a Code first instruction, 11 Excludes1 entries and 8 Excludes2 entries.
Code first
If the underlying condition listed here is present and known, sequence it first.
Excludes1
Not coded here. The listed conditions generally should not be reported together.
- diphtheritic pyelonephritis and tubulo-interstitial nephritis (A36.84)
- pyelonephritis and tubulo-interstitial nephritis in candidiasis (B37.49)
- pyelonephritis and tubulo-interstitial nephritis in cystinosis (E72.04)
- pyelonephritis and tubulo-interstitial nephritis in salmonella infection (A02.25)
- pyelonephritis and tubulo-interstitial nephritis in sarcoidosis (D86.84)
- pyelonephritis and tubulo-interstitial nephritis in Sjogren syndrome (M35.04)
- pyelonephritis and tubulo-interstitial nephritis in systemic lupus erythematosus (M32.15)
- pyelonephritis and tubulo-interstitial nephritis in toxoplasmosis (B58.83)
- renal tubular degeneration in diabetes (E08-E13 with .29)
- syphilitic pyelonephritis and tubulo-interstitial nephritis (A52.75)
Excludes2
Not included here. Both codes may be reported if the patient has both conditions.
Also from chapter/block level (8 notes)
- certain conditions originating in the perinatal period (P04-P96)
- certain infectious and parasitic diseases (A00-B99)
- complications of pregnancy, childbirth and the puerperium (O00-O9A)
- congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
- endocrine, nutritional and metabolic diseases (E00-E88)
- injury, poisoning and certain other consequences of external causes (S00-T88)
- neoplasms (C00-D49)
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
Care settings
How CMS programs treat this code. These are CMS claim edits and list entries, not coverage or eligibility rules.
Hospice: not accepted as primary
Not accepted as the principal diagnosis on a hospice claim (bill types 081x and 082x). The Integrated OCE returns an edit for this code.
Reason: Manifestation code. Report the underlying condition first (see the Code first note).
Includes
Further defines or gives examples of the content of the category.
Also from chapter/block level (1 note)
- pyelonephritis
Inclusion terms
Conditions classified to this code.
- Pyelonephritis
- Tubulo-interstitial nephritis
Alphabetic Index terms
Terms the official Alphabetic Index lists for this code. 22 entries
- Disorder (of), tubulo-interstitial (in), brucellosis
- Disorder (of), tubulo-interstitial (in), glycogen storage disease
- Disorder (of), tubulo-interstitial (in), leukemia NEC
- Disorder (of), tubulo-interstitial (in), lymphoma NEC
- Disorder (of), tubulo-interstitial (in), mixed cryoglobulinemia
- Disorder (of), tubulo-interstitial (in), multiple myeloma
- Disorder (of), tubulo-interstitial (in), sepsis
- Disorder (of), tubulo-interstitial (in), sepsis, streptococcal
- Disorder (of), tubulo-interstitial (in), transplant rejection
- Disorder (of), tubulo-interstitial (in), Wilson's disease
- Nephritis, nephritic (albuminuric) (azotemic) (congenital) (disseminated) (epithelial) (familial) (focal) (granulomatous) (hemorrhagic) (infantile) (nonsuppurative, excretory) (uremic), tubulo-interstitial (in), due to, brucellosis
- Nephritis, nephritic (albuminuric) (azotemic) (congenital) (disseminated) (epithelial) (familial) (focal) (granulomatous) (hemorrhagic) (infantile) (nonsuppurative, excretory) (uremic), tubulo-interstitial (in), due to, cryoglobulinemia
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- Nephritis, nephritic (albuminuric) (azotemic) (congenital) (disseminated) (epithelial) (familial) (focal) (granulomatous) (hemorrhagic) (infantile) (nonsuppurative, excretory) (uremic), tubulo-interstitial (in), due to, glycogen storage disease
- Pyelonephritis, in (due to), brucellosis
- Pyelonephritis, in (due to), cryoglobulinemia (mixed)
- Pyelonephritis, in (due to), glycogen storage disease
- Pyelonephritis, in (due to), leukemia NEC
- Pyelonephritis, in (due to), lymphoma NEC
- Pyelonephritis, in (due to), multiple myeloma
- Pyelonephritis, in (due to), sepsis
- Pyelonephritis, in (due to), transplant rejection
- Pyelonephritis, in (due to), Wilson's disease