I22.2
Subsequent non-ST elevation (NSTEMI) myocardial infarction
I22.2 (also written I222) is a billable ICD-10-CM diagnosis code for subsequent non-ST elevation (NSTEMI) myocardial infarction. It is part of the FY2027 code set, effective October 1, 2026. It is one of the 5 codes in category I22 (Subsequent ST elevation (STEMI) and non-ST elevation (NSTEMI) myocardial infarction). The Alphabetic Index lists it under 3 entries. Its coding notes include a Use additional code instruction, a Code also instruction, 2 Excludes1 entries and 10 Excludes2 entries.
Guidelines tip
From the FY2027 Official Guidelines. ICD10Ref adds no rules of its own.
I22 is only for a subsequent MI when both the initial and the subsequent MI are type 1 or unspecified. Subsequent type 2, 4 or 5 MIs have their own I21.A codes.
Use additional code
Add the listed code as a secondary code, if known.
- code, if applicable, to identify:
- exposure to environmental tobacco smoke (Z77.22)
- history of tobacco dependence (Z87.891)
- occupational exposure to environmental tobacco smoke (Z57.31)
- status post administration of tPA (rtPA) in a different facility within the last 24 hours prior to admission to current facility (Z92.82)
- tobacco dependence (F17.-)
- tobacco use (Z72.0)
Code also
Two codes may be needed to describe the condition. This note gives no sequencing order.
Excludes1
Not coded here. The listed conditions generally should not be reported together.
Excludes2
Not included here. Both codes may be reported if the patient has both conditions.
Also from chapter/block level (10 notes)
- certain conditions originating in the perinatal period (P04-P96)
- certain infectious and parasitic diseases (A00-B99)
- complications of pregnancy, childbirth and the puerperium (O00-O9A)
- congenital malformations, deformations, and chromosomal abnormalities (Q00-Q99)
- endocrine, nutritional and metabolic diseases (E00-E88)
- injury, poisoning and certain other consequences of external causes (S00-T88)
- neoplasms (C00-D49)
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
- systemic connective tissue disorders (M30-M36)
- transient cerebral ischemic attacks and related syndromes (G45.-)
Care settings
How CMS programs treat this code. These are CMS claim edits and list entries, not coverage or eligibility rules.
Home Health Primary
Accepted as the primary (principal) diagnosis on a home health claim. The Home Health Grouper assigns it to the MMTA - Cardiac and Circulatory clinical group.
Source: CMS Home Health Grouper Software v07.2.26, effective October 1, 2026Hospital MCC
Counts as a major complication or comorbidity (MCC) when reported as a secondary diagnosis on an inpatient claim. It does not count when the principal diagnosis is one of the 25 codes in its exclusion list. Some MS-DRGs also ignore a CC or MCC that defines the DRG.
Source: CMS MS-DRG Definitions Manual v44, effective October 1, 2026, Appendix CIncludes
Further defines or gives examples of the content of the category.
- acute myocardial infarction occurring within four weeks (28 days) of a previous acute myocardial infarction, regardless of site
- cardiac infarction
- coronary (artery) embolism
- coronary (artery) occlusion
- coronary (artery) rupture
- coronary (artery) thrombosis
- infarction of heart, myocardium, or ventricle
- recurrent myocardial infarction
- reinfarction of myocardium
- rupture of heart, myocardium, or ventricle
- subsequent type 1 myocardial infarction
Inclusion terms
Conditions classified to this code.
- Subsequent acute subendocardial myocardial infarction
- Subsequent non-Q wave myocardial infarction NOS
- Subsequent nontransmural myocardial infarction NOS
Alphabetic Index terms
Terms the official Alphabetic Index lists for this code. 3 entries
- Infarct, infarction, myocardium, myocardial (acute) (with stated duration of 4 weeks or less), non-ST elevation (NSTEMI), subsequent
- Infarct, infarction, myocardium, myocardial (acute) (with stated duration of 4 weeks or less), subsequent (recurrent) (reinfarction), non-ST elevation (NSTEMI)
- Infarct, infarction, myocardium, myocardial (acute) (with stated duration of 4 weeks or less), subsequent (recurrent) (reinfarction), subendocardial