E34.322
Insulin-like growth factor-1 (IGF-1) resistance
E34.322 (also written E34322) is a billable ICD-10-CM diagnosis code for insulin-like growth factor-1 (IGF-1) resistance. It is part of the FY2027 code set, effective October 1, 2026. It is one of the 18 codes in category E34 (Other endocrine disorders). The Alphabetic Index lists it under 4 entries. Its coding notes include 15 Excludes1 entries.
Excludes1
Not coded here. The listed conditions generally should not be reported together.
- achondroplastic short stature (Q77.4)
- hypochondroplastic short stature (Q77.4)
- nutritional short stature (E45)
- pituitary short stature (E23.0)
- progeria (E34.8)
- renal short stature (N25.0)
- Russell-Silver syndrome (Q87.19)
- short-limbed stature with immunodeficiency (D82.2)
- short stature (child) (R62.52)
- short stature in specific dysmorphic syndromes - code to syndrome - see Alphabetical Index
- short stature NOS (R62.52)
Care settings
How CMS programs treat this code. These are CMS claim edits and list entries, not coverage or eligibility rules.
Home Health Primary
Accepted as the primary (principal) diagnosis on a home health claim. The Home Health Grouper assigns it to the MMTA - Endocrine clinical group.
Source: CMS Home Health Grouper Software v07.2.26, effective October 1, 2026IRF 60% Rule
On the CMS list of diagnoses used to determine presumptive compliance with the IRF 60 percent rule.
Source: CMS IRF Presumptive Compliance-3, FY 2027 IRF PPS final rule files, effective for discharges on or after October 1, 2026Inclusion terms
Conditions classified to this code.
- Genetic syndrome with resistance to insulin-like growth factor-1
- Insulin-like growth factor-1 receptor (IGF-1R) defect
- Post-insulin-like growth factor-1 receptor signaling defect
Notes
Also from chapter/block level (1 note)
- All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
Alphabetic Index terms
Terms the official Alphabetic Index lists for this code. 4 entries
- Short, shortening, shortness, stature (child) (hereditary) (idiopathic) NEC, due to, genetic causes, genetic syndrome with resistance to insulin-like growth factor-1
- Short, shortening, shortness, stature (child) (hereditary) (idiopathic) NEC, due to, genetic causes, insulin-like growth factor-1 (IGF-1) resistance
- Short, shortening, shortness, stature (child) (hereditary) (idiopathic) NEC, due to, genetic causes, insulin-like growth factor-1 receptor (IGF-1R) defect
- Short, shortening, shortness, stature (child) (hereditary) (idiopathic) NEC, due to, genetic causes, post-insulin-like growth factor-1 receptor signaling defect