D75.81

Myelofibrosis

FY2027Chapter 3: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism/D70–D77 Other disorders of blood and blood-forming organs

BillableComplete code, valid to report

Code first
Use additional code
Excludes1
Excludes2

Care settingsHospice: not accepted as primary Hospital CC

D75.81 (also written D7581) is a billable ICD-10-CM diagnosis code for myelofibrosis. It is part of the FY2027 code set, effective October 1, 2026. It is one of the 13 codes in category D75 (Other and unspecified diseases of blood and blood-forming organs). The Alphabetic Index lists it under 4 entries. Its coding notes include a Code first instruction, a Use additional code instruction, 7 Excludes1 entries and 15 Excludes2 entries.

Code first

If the underlying condition listed here is present and known, sequence it first.

This code

the underlying disorder, such as:
- malignant neoplasm of breast (C50.-)

Use additional code

Add the listed code as a secondary code, if known.

This code

code, if applicable, for associated therapy-related myelodysplastic syndrome (D46.-)
code for adverse effect, if applicable, to identify drug (T45.1X5)

Excludes1

Not coded here. The listed conditions generally should not be reported together.

This code

acute myelofibrosis (C94.4-)
idiopathic myelofibrosis (D47.1)
leukoerythroblastic anemia (D61.82)
myelofibrosis with myeloid metaplasia (D47.4)
myelophthisic anemia (D61.82)
myelophthisis (D61.82)
primary myelofibrosis (D47.1)

Excludes2

Not included here. Both codes may be reported if the patient has both conditions.

Inherited from D75 Other and unspecified diseases of blood and blood-forming organs

acute lymphadenitis (L04.-)
chronic lymphadenitis (I88.1)
enlarged lymph nodes (R59.-)
hypergammaglobulinemia NOS (D89.2)
lymphadenitis NOS (I88.9)
mesenteric lymphadenitis (acute) (chronic) (I88.0)

Also from chapter/block level (9 notes)

Inherited from Chapter 3 Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

autoimmune disease (systemic) NOS (M35.9)
certain conditions originating in the perinatal period (P00-P96)
complications of pregnancy, childbirth and the puerperium (O00-O9A)
congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
endocrine, nutritional and metabolic diseases (E00-E88)
human immunodeficiency virus [HIV] disease (B20)
injury, poisoning and certain other consequences of external causes (S00-T88)
neoplasms (C00-D49)
symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)

Care settings

How CMS programs treat this code. These are CMS claim edits and list entries, not coverage or eligibility rules.

Hospice: not accepted as primary

Not accepted as the principal diagnosis on a hospice claim (bill types 081x and 082x). The Integrated OCE returns an edit for this code.
Reason: Manifestation code. Report the underlying condition first (see the Code first note).

Source: CMS Integrated Outpatient Code Editor (IOCE) v27.3, effective October 1, 2026, edit 86

Hospital CC

Counts as a complication or comorbidity (CC) when reported as a secondary diagnosis on an inpatient claim. It does not count when the principal diagnosis is one of the 133 codes in its exclusion list. Some MS-DRGs also ignore a CC or MCC that defines the DRG.

Source: CMS MS-DRG Definitions Manual v44, effective October 1, 2026, Appendix C

Inclusion terms

Conditions classified to this code.

This code

Myelofibrosis NOS
Secondary myelofibrosis NOS

Alphabetic Index terms

Terms the official Alphabetic Index lists for this code. 4 entries