D57.21
Sickle-cell/Hb-C disease with crisis
D57.21 is a non-billable ICD-10-CM code header for sickle-cell/Hb-C disease with crisis. Report a more specific code from it instead. It is part of the FY2027 code set, effective October 1, 2026. The more specific codes under it are D57.211 Sickle-cell/Hb-C disease with acute chest syndrome, D57.212 Sickle-cell/Hb-C disease with splenic sequestration, D57.213 Sickle-cell/Hb-C disease with cerebral vascular involvement, D57.214 Sickle-cell/Hb-C disease with dactylitis and 2 more. Its coding notes include a Use additional code instruction, 1 Excludes1 entry and 9 Excludes2 entries.
Use additional code
Add the listed code as a secondary code, if known.
Excludes1
Not coded here. The listed conditions generally should not be reported together.
Excludes2
Not included here. Both codes may be reported if the patient has both conditions.
Also from chapter/block level (9 notes)
- autoimmune disease (systemic) NOS (M35.9)
- certain conditions originating in the perinatal period (P00-P96)
- complications of pregnancy, childbirth and the puerperium (O00-O9A)
- congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
- endocrine, nutritional and metabolic diseases (E00-E88)
- human immunodeficiency virus [HIV] disease (B20)
- injury, poisoning and certain other consequences of external causes (S00-T88)
- neoplasms (C00-D49)
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
More specific codes under D57.21 6
- D57.211Sickle-cell/Hb-C disease with acute chest syndromeBillable
- D57.212Sickle-cell/Hb-C disease with splenic sequestrationBillable
- D57.213Sickle-cell/Hb-C disease with cerebral vascular involvementBillable
- D57.214Sickle-cell/Hb-C disease with dactylitisBillable
- D57.218Sickle-cell/Hb-C disease with crisis with other specified complicationBillable
- D57.219Sickle-cell/Hb-C disease with crisis, unspecifiedBillable