D53.0
Protein deficiency anemia
D53.0 (also written D530) is a billable ICD-10-CM diagnosis code for protein deficiency anemia. It is part of the FY2027 code set, effective October 1, 2026. It is one of the 5 codes in category D53 (Other nutritional anemias). The Alphabetic Index lists it under 12 entries. Its coding notes include 1 Excludes1 entry and 9 Excludes2 entries.
Excludes1
Not coded here. The listed conditions generally should not be reported together.
- Lesch-Nyhan syndrome (E79.1)
Excludes2
Not included here. Both codes may be reported if the patient has both conditions.
Also from chapter/block level (9 notes)
- autoimmune disease (systemic) NOS (M35.9)
- certain conditions originating in the perinatal period (P00-P96)
- complications of pregnancy, childbirth and the puerperium (O00-O9A)
- congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
- endocrine, nutritional and metabolic diseases (E00-E88)
- human immunodeficiency virus [HIV] disease (B20)
- injury, poisoning and certain other consequences of external causes (S00-T88)
- neoplasms (C00-D49)
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
Care settings
How CMS programs treat this code. These are CMS claim edits and list entries, not coverage or eligibility rules.
Home Health Primary
Accepted as the primary (principal) diagnosis on a home health claim. The Home Health Grouper assigns it to the MMTA - Infectious Disease, Neoplasms, and Blood-Forming Diseases clinical group.
Source: CMS Home Health Grouper Software v07.2.26, effective October 1, 2026Includes
Further defines or gives examples of the content of the category.
- megaloblastic anemia unresponsive to vitamin B12 or folate therapy
Inclusion terms
Conditions classified to this code.
- Amino-acid deficiency anemia
- Orotaciduric anemia
Alphabetic Index terms
Terms the official Alphabetic Index lists for this code. 12 entries
- Aciduria, orotic (congenital) (hereditary) (pyrimidine deficiency), anemia
- Amino-acid disorder, anemia
- Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound), amino-acid-deficiency
- Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound), deficiency, amino-acid
- Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound), deficiency, protein
- Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound), due to (in) (with), deficiency, amino-acid
- Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound), due to (in) (with), deficiency, protein
- Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound), megaloblastic, orotic aciduria
- Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound), orotaciduric (congenital) (hereditary)
- Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound), protein-deficiency
- Deficiency, deficient, protein, anemia
- Orotaciduria, oroticaciduria (congenital) (hereditary) (pyrimidine deficiency), anemia