Z15.8

Genetic susceptibility to other disease

FY2027Chapter 21: Factors influencing health status and contact with health services/Z14–Z15 Genetic carrier and genetic susceptibility to disease

Non-billable headerNot valid on its own. Use one of the more specific codes under it.

Z15.8 is a non-billable ICD-10-CM code header for genetic susceptibility to other disease. Report a more specific code from it instead. It is part of the FY2027 code set, effective October 1, 2026. The more specific codes under it are Z15.81 Genetic susceptibility to multiple endocrine neoplasia [MEN] and Z15.89 Genetic susceptibility to other disease. Its coding notes include a Use additional code instruction and 1 Excludes1 entry.

Use additional code

Add the listed code as a secondary code, if known.

Inherited from Z15 Genetic susceptibility to disease
  • code, if applicable, for any associated family history of the disease (Z80-Z84)

Excludes1

Not coded here. The listed conditions generally should not be reported together.

Inherited from Z15 Genetic susceptibility to disease

Includes

Further defines or gives examples of the content of the category.

Inherited from Z15 Genetic susceptibility to disease
  • confirmed abnormal gene

Notes

Also from chapter/block level (3 notes)
Inherited from Chapter 21 Factors influencing health status and contact with health services
  • Z codes represent reasons for encounters. A corresponding procedure code must accompany a Z code if a procedure is performed. Categories Z00-Z99 are provided for occasions when circumstances other than a disease, injury or external cause classifiable to categories A00-Y89 are recorded as 'diagnoses' or 'problems'. This can arise in two main ways:
    • (a) When a person who may or may not be sick encounters the health services for some specific purpose, such as to receive limited care or service for a current condition, to donate an organ or tissue, to receive prophylactic vaccination (immunization), or to discuss a problem which is in itself not a disease or injury.
    • (b) When some circumstance or problem is present which influences the person's health status but is not in itself a current illness or injury.

More specific codes under Z15.8 2