R45.1
Restlessness and agitation
R45.1 (also written R451) is a billable ICD-10-CM diagnosis code for restlessness and agitation. It is part of the FY2027 code set, effective October 1, 2026. It is one of the 18 codes in category R45 (Symptoms and signs involving emotional state). The Alphabetic Index lists it under 4 entries. Its coding notes include 5 Excludes2 entries.
Guidelines tip
From the FY2027 Official Guidelines. ICD10Ref adds no rules of its own.
Symptom and sign codes are acceptable when no definitive diagnosis has been established. They are not added for signs that are routinely associated with a diagnosis.
Excludes2
Not included here. Both codes may be reported if the patient has both conditions.
Also from chapter/block level (5 notes)
- symptoms and signs constituting part of a pattern of mental disorder (F01-F99)
Care settings
How CMS programs treat this code. These are CMS claim edits and list entries, not coverage or eligibility rules.
IPF Primary
IPF MS-DRG adjustment. A principal diagnosis of this code groups to this MS-DRG:
| MS-DRG | Description | Factor |
|---|---|---|
| 884 | Organic disturbances & intellectual disabilities | 1.08 |
IPF Comorbidity
On the CMS IPF comorbidity list.
| Comorbidity category | Factor |
|---|---|
| Intensive Management for High-Risk Behavior | 1.07 |
Notes
Also from chapter/block level (9 notes)
- This chapter includes symptoms, signs, abnormal results of clinical or other investigative procedures, and ill-defined conditions regarding which no diagnosis classifiable elsewhere is recorded.
- Signs and symptoms that point rather definitely to a given diagnosis have been assigned to a category in other chapters of the classification. In general, categories in this chapter include the less well-defined conditions and symptoms that, without the necessary study of the case to establish a final diagnosis, point perhaps equally to two or more diseases or to two or more systems of the body. Practically all categories in the chapter could be designated 'not otherwise specified', 'unknown etiology' or 'transient'. The Alphabetical Index should be consulted to determine which symptoms and signs are to be allocated here and which to other chapters. The residual subcategories, numbered .8, are generally provided for other relevant symptoms that cannot be allocated elsewhere in the classification.
- The conditions and signs or symptoms included in categories R00-R94 consist of:
- (a) cases for which no more specific diagnosis can be made even after all the facts bearing on the case have been investigated;
- (b) signs or symptoms existing at the time of initial encounter that proved to be transient and whose causes could not be determined;
- (c) provisional diagnosis in a patient who failed to return for further investigation or care;
- (d) cases referred elsewhere for investigation or treatment before the diagnosis was made;
- (e) cases in which a more precise diagnosis was not available for any other reason;
- (f) certain symptoms, for which supplementary information is provided, that represent important problems in medical care in their own right.
Alphabetic Index terms
Terms the official Alphabetic Index lists for this code. 4 entries