QA0.0142

DLG4-related synaptopathy

FY2027Chapter 17: Congenital malformations, deformations, chromosomal abnormalities, and genetic disorders/QA0–QA1 Genetic disorders, not elsewhere classified

BillableComplete code, valid to report

QA0.0142 (also written QA00142) is a billable ICD-10-CM diagnosis code for DLG4-related synaptopathy. It is part of the FY2027 code set, effective October 1, 2026. It is one of the 13 codes in category QA0 (Neurodevelopmental disorders related to specific genetic pathogenic variants). The Alphabetic Index lists it under 2 entries. Its coding notes include a Code also instruction and 1 Excludes2 entry.

Guidelines tip

From the FY2027 Official Guidelines. ICD10Ref adds no rules of its own.

Chapter 17 codes can be used for life. Manifestations that are an inherent part of a specifically coded anomaly are not coded separately. A corrected malformation is reported with a personal history code.

Guidelines I.C.17Congenital malformations and genetic disordersRead the official text

Code also

Two codes may be needed to describe the condition. This note gives no sequencing order.

Inherited from QA0 Neurodevelopmental disorders related to specific genetic pathogenic variants
  • , if applicable, any associated conditions, such as:
    • attention-deficit hyperactivity disorders (F90.-)
    • autism spectrum disorder (F84.0)
    • developmental and epileptic encephalopathy (G93.45)
    • epilepsy, by specific type (G40.-)
    • intellectual disabilities (F70-F79)
    • pervasive developmental disorders (F84.-)

Excludes2

Not included here. Both codes may be reported if the patient has both conditions.

Also from chapter/block level (1 note)
Inherited from Chapter 17 Congenital malformations, deformations, chromosomal abnormalities, and genetic disorders
  • inborn errors of metabolism (E70-E88)

Care settings

How CMS programs treat this code. These are CMS claim edits and list entries, not coverage or eligibility rules.

Home Health Primary

Accepted as the primary (principal) diagnosis on a home health claim. The Home Health Grouper assigns it to the Neuro Rehabilitation clinical group.

Source: CMS Home Health Grouper Software v07.2.26, effective October 1, 2026

Hospital CC

Counts as a complication or comorbidity (CC) when reported as a secondary diagnosis on an inpatient claim. It does not count when the principal diagnosis is one of the 40 codes in its exclusion list. Some MS-DRGs also ignore a CC or MCC that defines the DRG.

Source: CMS MS-DRG Definitions Manual v44, effective October 1, 2026, Appendix C

Notes

Also from chapter/block level (1 note)
Inherited from Chapter 17 Congenital malformations, deformations, chromosomal abnormalities, and genetic disorders
  • Codes from this chapter are not for use on maternal records

Alphabetic Index terms

Terms the official Alphabetic Index lists for this code. 2 entries