N25.81
Secondary hyperparathyroidism of renal origin
N25.81 (also written N2581) is a billable ICD-10-CM diagnosis code for secondary hyperparathyroidism of renal origin. It is part of the FY2027 code set, effective October 1, 2026. It is one of the 5 codes in category N25 (Disorders resulting from impaired renal tubular function). The Alphabetic Index lists it under 1 entry. Its coding notes include 1 Excludes1 entry and 10 Excludes2 entries.
Excludes1
Not coded here. The listed conditions generally should not be reported together.
- secondary hyperparathyroidism, non-renal (E21.1)
Excludes2
Not included here. Both codes may be reported if the patient has both conditions.
- metabolic disorders classifiable to E70-E88
Also from chapter/block level (9 notes)
- disorders of kidney and ureter with urolithiasis (N20-N23)
- certain conditions originating in the perinatal period (P04-P96)
- certain infectious and parasitic diseases (A00-B99)
- complications of pregnancy, childbirth and the puerperium (O00-O9A)
- congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
- endocrine, nutritional and metabolic diseases (E00-E88)
- injury, poisoning and certain other consequences of external causes (S00-T88)
- neoplasms (C00-D49)
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
Care settings
How CMS programs treat this code. These are CMS claim edits and list entries, not coverage or eligibility rules.
Home Health Primary
Accepted as the primary (principal) diagnosis on a home health claim. The Home Health Grouper assigns it to the MMTA - Gastrointestinal tract and Genitourinary system clinical group.
Source: CMS Home Health Grouper Software v07.2.26, effective October 1, 2026Hospital CC
Counts as a complication or comorbidity (CC) when reported as a secondary diagnosis on an inpatient claim. It does not count when the principal diagnosis is one of the 269 codes in its exclusion list. Some MS-DRGs also ignore a CC or MCC that defines the DRG.
Source: CMS MS-DRG Definitions Manual v44, effective October 1, 2026, Appendix CAlphabetic Index terms
Terms the official Alphabetic Index lists for this code. 1 entry