H21.81
Floppy iris syndrome
H21.81 (also written H2181) is a billable ICD-10-CM diagnosis code for floppy iris syndrome. It is part of the FY2027 code set, effective October 1, 2026. It is one of the 97 codes in category H21 (Other disorders of iris and ciliary body). The Alphabetic Index lists it under 2 entries. Its coding notes include a Use additional code instruction and 12 Excludes2 entries.
Use additional code
Add the listed code as a secondary code, if known.
- code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)
Excludes2
Not included here. Both codes may be reported if the patient has both conditions.
Also from chapter/block level (11 notes)
- certain conditions originating in the perinatal period (P04-P96)
- certain infectious and parasitic diseases (A00-B99)
- complications of pregnancy, childbirth and the puerperium (O00-O9A)
- congenital malformations, deformations, and chromosomal abnormalities (Q00-Q99)
- diabetes mellitus related eye conditions (E09.3-, E10.3-, E11.3-, E13.3-)
- endocrine, nutritional and metabolic diseases (E00-E88)
- injury (trauma) of eye and orbit (S05.-)
- injury, poisoning and certain other consequences of external causes (S00-T88)
- neoplasms (C00-D49)
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
- syphilis related eye disorders (A50.01, A50.3-, A51.43, A52.71)
Care settings
How CMS programs treat this code. These are CMS claim edits and list entries, not coverage or eligibility rules.
Home Health Primary
Accepted as the primary (principal) diagnosis on a home health claim. The Home Health Grouper assigns it to the MMTA - Other clinical group.
Source: CMS Home Health Grouper Software v07.2.26, effective October 1, 2026Inclusion terms
Conditions classified to this code.
- Intraoperative floppy iris syndrome (IFIS)
Notes
Also from chapter/block level (1 note)
- Use an external cause code following the code for the eye condition, if applicable, to identify the cause of the eye condition
Alphabetic Index terms
Terms the official Alphabetic Index lists for this code. 2 entries