Alphabetic Index FY2027

F33.3

Major depressive disorder, recurrent, severe with psychotic symptoms

FY2027Chapter 5: Mental, Behavioral and Neurodevelopmental disorders/F30–F39 Mood [affective] disorders

BillableComplete code, valid to report
Care settingsHome Health Primary · Behavioral HealthHospital CCIPF Primary · MS-DRG 885

F33.3 (also written F333) is a billable ICD-10-CM diagnosis code for major depressive disorder, recurrent, severe with psychotic symptoms. It is part of the FY2027 code set, effective October 1, 2026. It is one of the 9 codes in category F33 (Major depressive disorder, recurrent). The Alphabetic Index lists it under 6 entries. Its coding notes include 2 Excludes1 entries and 1 Excludes2 entry.

Excludes1

Not coded here. The listed conditions generally should not be reported together.

Inherited from F33 Major depressive disorder, recurrent

Excludes2

Not included here. Both codes may be reported if the patient has both conditions.

Also from chapter/block level (1 note)
Inherited from Chapter 5 Mental, Behavioral and Neurodevelopmental disorders
  • symptoms, signs and abnormal clinical laboratory findings, not elsewhere classified (R00-R99)

Care settings

How CMS programs treat this code. These are CMS claim edits and list entries, not coverage or eligibility rules.

Home Health Primary

Accepted as the primary (principal) diagnosis on a home health claim. The Home Health Grouper assigns it to the Behavioral Health clinical group.

Source: CMS Home Health Grouper Software v07.2.26, effective October 1, 2026

Hospital CC

Counts as a complication or comorbidity (CC) when reported as a secondary diagnosis on an inpatient claim. It does not count when the principal diagnosis is one of the 293 codes in its exclusion list. Some MS-DRGs also ignore a CC or MCC that defines the DRG.

Source: CMS MS-DRG Definitions Manual v44, effective October 1, 2026, Appendix C

IPF Primary

IPF MS-DRG adjustment. A principal diagnosis of this code groups to this MS-DRG:

MS-DRGDescriptionFactor
885Psychoses1.00
A principal diagnosis that groups to none of the 19 designated MS-DRGs gets no MS-DRG adjustment. Otherwise the claim still receives the federal per diem base rate and the other adjustments.

Source: CMS IPF PPS FY 2027 final rule (CMS-1847-F), Addendum A; code lists from the CMS MS-DRG Definitions Manual v44; effective for discharges on or after October 1, 2026

Includes

Further defines or gives examples of the content of the category.

Inherited from F33 Major depressive disorder, recurrent
  • recurrent episodes of depressive reaction
  • recurrent episodes of endogenous depression
  • recurrent episodes of major depression
  • recurrent episodes of psychogenic depression
  • recurrent episodes of reactive depression
  • recurrent episodes of seasonal affective disorder
  • recurrent episodes of seasonal depressive disorder
  • recurrent episodes of vital depression
Also from chapter/block level (1 note)
Inherited from Chapter 5 Mental, Behavioral and Neurodevelopmental disorders
  • disorders of psychological development

Inclusion terms

Conditions classified to this code.

This code
  • Endogenous depression with psychotic symptoms
  • Major depressive disorder, recurrent, with psychotic features
  • Recurrent severe episodes of major depression with mood-congruent psychotic symptoms
  • Recurrent severe episodes of major depression with mood-incongruent psychotic symptoms
  • Recurrent severe episodes of major depression with psychotic symptoms
  • Recurrent severe episodes of psychogenic depressive psychosis
  • Recurrent severe episodes of psychotic depression
  • Recurrent severe episodes of reactive depressive psychosis

Alphabetic Index terms

Terms the official Alphabetic Index lists for this code. 6 entries