Alphabetic Index FY2027

D89.83

Cytokine release syndrome

FY2027Chapter 3: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism/D80–D89 Certain disorders involving the immune mechanism

Non-billable headerNot valid on its own. Use one of the more specific codes under it.

D89.83 is a non-billable ICD-10-CM code header for cytokine release syndrome. Report a more specific code from it instead. It is part of the FY2027 code set, effective October 1, 2026. The more specific codes under it are D89.831 Cytokine release syndrome, grade 1; D89.832 Cytokine release syndrome, grade 2; D89.833 Cytokine release syndrome, grade 3; D89.834 Cytokine release syndrome, grade 4 and 2 more. Its coding notes include a Code first instruction, a Use additional code instruction, 4 Excludes1 entries and 11 Excludes2 entries.

Code first

If the underlying condition listed here is present and known, sequence it first.

This code
  • underlying cause, such as:
    • complications following infusion, transfusion and therapeutic injection (T80.89-)
    • complications of transplanted organs and tissue (T86.-)

Use additional code

Add the listed code as a secondary code, if known.

This code
  • code for adverse effect, if applicable, to identify immune checkpoint inhibitors and immunostimulant drugs (T45.AX5)
  • code to identify associated manifestations

Excludes1

Not coded here. The listed conditions generally should not be reported together.

Inherited from D89 Other disorders involving the immune mechanism, not elsewhere classified
  • hyperglobulinemia NOS (R77.1)
  • monoclonal gammopathy (of undetermined significance) (D47.2)
Also from chapter/block level (2 notes)
Inherited from D80–D89 Certain disorders involving the immune mechanism
  • autoimmune disease (systemic) NOS (M35.9)
  • functional disorders of polymorphonuclear neutrophils (D71-)

Excludes2

Not included here. Both codes may be reported if the patient has both conditions.

Inherited from D89 Other disorders involving the immune mechanism, not elsewhere classified
  • transplant failure and rejection (T86.-)
Also from chapter/block level (10 notes)
Inherited from D80–D89 Certain disorders involving the immune mechanism
  • human immunodeficiency virus [HIV] disease (B20)
Inherited from Chapter 3 Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
  • autoimmune disease (systemic) NOS (M35.9)
  • certain conditions originating in the perinatal period (P00-P96)
  • complications of pregnancy, childbirth and the puerperium (O00-O9A)
  • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
  • endocrine, nutritional and metabolic diseases (E00-E88)
  • human immunodeficiency virus [HIV] disease (B20)
  • injury, poisoning and certain other consequences of external causes (S00-T88)
  • neoplasms (C00-D49)
  • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)

Includes

Further defines or gives examples of the content of the category.

Also from chapter/block level (3 notes)
Inherited from D80–D89 Certain disorders involving the immune mechanism
  • defects in the complement system
  • immunodeficiency disorders, except human immunodeficiency virus [HIV] disease
  • sarcoidosis

More specific codes under D89.83 6