D81.8
Other combined immunodeficiencies
Non-billable headerNot valid on its own. Use one of the more specific codes under it.
D81.8 is a non-billable ICD-10-CM code header for other combined immunodeficiencies. Report a more specific code from it instead. It is part of the FY2027 code set, effective October 1, 2026. The more specific codes under it are D81.81 Biotin-dependent carboxylase deficiency, D81.82 Activated Phosphoinositide 3-kinase Delta Syndrome [APDS] and D81.89 Other combined immunodeficiencies. Its coding notes include 3 Excludes1 entries and 10 Excludes2 entries.
Excludes1
Not coded here. The listed conditions generally should not be reported together.
Excludes2
Not included here. Both codes may be reported if the patient has both conditions.
Also from chapter/block level (10 notes)
Inherited from D80–D89 Certain disorders involving the immune mechanism
- human immunodeficiency virus [HIV] disease (B20)
Inherited from Chapter 3 Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- autoimmune disease (systemic) NOS (M35.9)
- certain conditions originating in the perinatal period (P00-P96)
- complications of pregnancy, childbirth and the puerperium (O00-O9A)
- congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
- endocrine, nutritional and metabolic diseases (E00-E88)
- human immunodeficiency virus [HIV] disease (B20)
- injury, poisoning and certain other consequences of external causes (S00-T88)
- neoplasms (C00-D49)
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
Includes
Further defines or gives examples of the content of the category.
Also from chapter/block level (3 notes)
Inherited from D80–D89 Certain disorders involving the immune mechanism
- defects in the complement system
- immunodeficiency disorders, except human immunodeficiency virus [HIV] disease
- sarcoidosis