D72.81

Decreased white blood cell count

FY2027Chapter 3: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism/D70–D77 Other disorders of blood and blood-forming organs

Non-billable headerNot valid on its own. Use one of the more specific codes under it.

D72.81 is a non-billable ICD-10-CM code header for decreased white blood cell count. Report a more specific code from it instead. It is part of the FY2027 code set, effective October 1, 2026. The more specific codes under it are D72.810 Lymphocytopenia; D72.818 Other decreased white blood cell count and D72.819 Decreased white blood cell count, unspecified. Its coding notes include 4 Excludes1 entries and 11 Excludes2 entries.

Excludes1

Not coded here. The listed conditions generally should not be reported together.

Inherited from D72.8 Other specified disorders of white blood cells
  • leukemia (C91-C95)
Inherited from D72 Other disorders of white blood cells

Excludes2

Not included here. Both codes may be reported if the patient has both conditions.

This code
  • neutropenia (D70)
Inherited from D72 Other disorders of white blood cells
  • neutropenia (D70)
Also from chapter/block level (9 notes)
Inherited from Chapter 3 Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
  • autoimmune disease (systemic) NOS (M35.9)
  • certain conditions originating in the perinatal period (P00-P96)
  • complications of pregnancy, childbirth and the puerperium (O00-O9A)
  • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
  • endocrine, nutritional and metabolic diseases (E00-E88)
  • human immunodeficiency virus [HIV] disease (B20)
  • injury, poisoning and certain other consequences of external causes (S00-T88)
  • neoplasms (C00-D49)
  • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)

More specific codes under D72.81 3