D49.2
Neoplasm of unspecified behavior of bone, soft tissue, and skin
D49.2 (also written D492) is a billable ICD-10-CM diagnosis code for neoplasm of unspecified behavior of bone, soft tissue, and skin. It is part of the FY2027 code set, effective October 1, 2026. It is one of the 14 codes in category D49 (Neoplasms of unspecified behavior). The Alphabetic Index lists it under 21 entries. Its coding notes include 8 Excludes1 entries and 1 Excludes2 entry.
Excludes1
Not coded here. The listed conditions generally should not be reported together.
- neoplasm of unspecified behavior of anal canal (D49.0)
- neoplasm of unspecified behavior of anus NOS (D49.0)
- neoplasm of unspecified behavior of bone marrow (D49.89)
- neoplasm of unspecified behavior of cartilage of larynx (D49.1)
- neoplasm of unspecified behavior of cartilage of nose (D49.1)
- neoplasm of unspecified behavior of connective tissue of breast (D49.3)
- neoplasm of unspecified behavior of skin of genital organs (D49.59)
- neoplasm of unspecified behavior of vermilion border of lip (D49.0)
Excludes2
Not included here. Both codes may be reported if the patient has both conditions.
Care settings
How CMS programs treat this code. These are CMS claim edits and list entries, not coverage or eligibility rules.
Home Health Primary
Accepted as the primary (principal) diagnosis on a home health claim. The Home Health Grouper assigns it to the MMTA - Infectious Disease, Neoplasms, and Blood-Forming Diseases clinical group.
Source: CMS Home Health Grouper Software v07.2.26, effective October 1, 2026IPF Comorbidity
On the CMS IPF comorbidity list.
| Comorbidity category | Factor |
|---|---|
| Oncology Treatment | 1.44 |
Includes
Further defines or gives examples of the content of the category.
- 'growth' NOS
- neoplasm NOS
- new growth NOS
- tumor NOS
Notes
- Category D49 classifies by site neoplasms of unspecified morphology and behavior. The term 'mass', unless otherwise stated, is not to be regarded as a neoplastic growth.
Also from chapter/block level (8 notes)
- Functional activity
- All neoplasms are classified in this chapter, whether they are functionally active or not. An additional code from Chapter 4 may be used, to identify functional activity associated with any neoplasm.
- Morphology [Histology]
- Chapter 2 classifies neoplasms primarily by site (topography), with broad groupings for behavior, malignant, in situ, benign, etc. The Table of Neoplasms should be used to identify the correct topography code. In a few cases, such as for malignant melanoma and certain neuroendocrine tumors, the morphology (histologic type) is included in the category and codes.
- Primary malignant neoplasms overlapping site boundaries
- A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified to the subcategory/code .8 ('overlapping lesion'), unless the combination is specifically indexed elsewhere. For multiple neoplasms of the same site that are not contiguous, such as tumors in different quadrants of the same breast, codes for each site should be assigned.
- Malignant neoplasm of ectopic tissue
- Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ectopic pancreatic malignant neoplasms are coded to pancreas, unspecified (C25.9).
Alphabetic Index terms
Terms the official Alphabetic Index lists for this code. 21 entries
- Osteitis, deformans, in (due to), neoplastic disease, carpus
- Osteitis, deformans, in (due to), neoplastic disease, clavicle
- Osteitis, deformans, in (due to), neoplastic disease, femur
- Osteitis, deformans, in (due to), neoplastic disease, fibula
- Osteitis, deformans, in (due to), neoplastic disease, finger
- Osteitis, deformans, in (due to), neoplastic disease, humerus
- Osteitis, deformans, in (due to), neoplastic disease, ilium
- Osteitis, deformans, in (due to), neoplastic disease, ischium
- Osteitis, deformans, in (due to), neoplastic disease, metacarpus
- Osteitis, deformans, in (due to), neoplastic disease, metatarsus
- Osteitis, deformans, in (due to), neoplastic disease, neck
- Osteitis, deformans, in (due to), neoplastic disease, pubic ramus
Show 9 more
- Osteitis, deformans, in (due to), neoplastic disease, radius
- Osteitis, deformans, in (due to), neoplastic disease, rib
- Osteitis, deformans, in (due to), neoplastic disease, scapula
- Osteitis, deformans, in (due to), neoplastic disease, skull
- Osteitis, deformans, in (due to), neoplastic disease, tarsus
- Osteitis, deformans, in (due to), neoplastic disease, tibia
- Osteitis, deformans, in (due to), neoplastic disease, toe
- Osteitis, deformans, in (due to), neoplastic disease, ulna
- Osteitis, deformans, in (due to), neoplastic disease, vertebra