A52.8
Late syphilis, latent
A52.8 (also written A528) is a billable ICD-10-CM diagnosis code for late syphilis, latent. It is part of the FY2027 code set, effective October 1, 2026. It is one of the 30 codes in category A52 (Late syphilis). The Alphabetic Index lists it under 6 entries. Its coding notes include a Use additional code instruction, 2 Excludes1 entries and 6 Excludes2 entries.
Use additional code
Add the listed code as a secondary code, if known.
Excludes1
Not coded here. The listed conditions generally should not be reported together.
Excludes2
Not included here. Both codes may be reported if the patient has both conditions.
Also from chapter/block level (6 notes)
- human immunodeficiency virus [HIV] disease (B20)
- carrier or suspected carrier of infectious disease (Z22.-)
- certain localized infections - see body system-related chapters
- infectious and parasitic diseases complicating pregnancy, childbirth and the puerperium (O98.-)
- infectious and parasitic diseases specific to the perinatal period (P35-P39)
- influenza and other acute respiratory infections (J00-J22)
Care settings
How CMS programs treat this code. These are CMS claim edits and list entries, not coverage or eligibility rules.
Home Health Primary
Accepted as the primary (principal) diagnosis on a home health claim. The Home Health Grouper assigns it to the MMTA - Infectious Disease, Neoplasms, and Blood-Forming Diseases clinical group.
Source: CMS Home Health Grouper Software v07.2.26, effective October 1, 2026Includes
Further defines or gives examples of the content of the category.
Also from chapter/block level (1 note)
- diseases generally recognized as communicable or transmissible
Inclusion terms
Conditions classified to this code.
- Syphilis (acquired) without clinical manifestations, with positive serological reaction and negative spinal fluid test, two years or more after infection
Alphabetic Index terms
Terms the official Alphabetic Index lists for this code. 6 entries
- Syphilis, syphilitic (acquired), late, latent or 2 years or more after infection (without manifestations)
- Syphilis, syphilitic (acquired), late, latent or 2 years or more after infection (without manifestations), negative spinal fluid test
- Syphilis, syphilitic (acquired), late, latent or 2 years or more after infection (without manifestations), serology positive
- Syphilis, syphilitic (acquired), latent, follow-up of latent syphilis, late, or 2 years or more after infection
- Syphilis, syphilitic (acquired), latent, late, or 2 years or more after infection
- Syphilis, syphilitic (acquired), latent, positive serology (only finding), late, or 2 years or more after infection