Z17.3

Human epidermal growth factor 2 receptor

FY2027Chapter 21: Factors influencing health status and contact with health services/Z17 Estrogen, and other hormones and factors receptor status

Non-billable headerNot valid on its own. Use one of the more specific codes under it.

Z17.3 is a non-billable ICD-10-CM code header for human epidermal growth factor 2 receptor. Report a more specific code from it instead. It is part of the FY2027 code set, effective October 1, 2026. The more specific codes under it are Z17.31 Human epidermal growth factor receptor 2 positive status and Z17.32 Human epidermal growth factor receptor 2 negative status. Its coding notes include a Code first instruction.

Code first

If the underlying condition listed here is present and known, sequence it first.

Inherited from Z17 Estrogen, and other hormones and factors receptor status
  • malignant neoplasm, such as:
    • malignant neoplasm of breast (C50.-)
    • malignant neoplasm of ovary (C56.-)

Notes

Inherited from Z17 Estrogen, and other hormones and factors receptor status
Also from chapter/block level (3 notes)
Inherited from Chapter 21 Factors influencing health status and contact with health services
  • Z codes represent reasons for encounters. A corresponding procedure code must accompany a Z code if a procedure is performed. Categories Z00-Z99 are provided for occasions when circumstances other than a disease, injury or external cause classifiable to categories A00-Y89 are recorded as 'diagnoses' or 'problems'. This can arise in two main ways:
    • (a) When a person who may or may not be sick encounters the health services for some specific purpose, such as to receive limited care or service for a current condition, to donate an organ or tissue, to receive prophylactic vaccination (immunization), or to discuss a problem which is in itself not a disease or injury.
    • (b) When some circumstance or problem is present which influences the person's health status but is not in itself a current illness or injury.

More specific codes under Z17.3 2