Alphabetic Index FY2027

Z16.2

Resistance to other antibiotics

FY2027Chapter 21: Factors influencing health status and contact with health services/Z16 Resistance to antimicrobial drugs

Non-billable headerNot valid on its own. Use one of the more specific codes under it.

Z16.2 is a non-billable ICD-10-CM code header for resistance to other antibiotics. Report a more specific code from it instead. It is part of the FY2027 code set, effective October 1, 2026. The more specific codes under it are Z16.20 Resistance to unspecified antibiotic, Z16.21 Resistance to vancomycin, Z16.22 Resistance to vancomycin related antibiotics, Z16.23 Resistance to quinolones and fluoroquinolones and 2 more. Its coding notes include a Code first instruction and 3 Excludes1 entries.

Guidelines tip

From the FY2027 Official Guidelines. ICD10Ref adds no rules of its own.

A Z16 code follows the infection code only if the infection code does not itself identify drug resistance.

Guidelines I.C.1.cResistance to antimicrobial drugs (Z16)Read the official text

Code first

If the underlying condition listed here is present and known, sequence it first.

Inherited from Z16 Resistance to antimicrobial drugs
  • the infection

Excludes1

Not coded here. The listed conditions generally should not be reported together.

Inherited from Z16 Resistance to antimicrobial drugs
  • Methicillin resistant Staphylococcus aureus infection (A49.02)
  • Methicillin resistant Staphylococcus aureus pneumonia (J15.212)
  • Sepsis due to Methicillin resistant Staphylococcus aureus (A41.02)

Notes

Inherited from Z16 Resistance to antimicrobial drugs
  • The codes in this category are provided for use as additional codes to identify the resistance and non-responsiveness of a condition to antimicrobial drugs.
Also from chapter/block level (3 notes)
Inherited from Chapter 21 Factors influencing health status and contact with health services
  • Z codes represent reasons for encounters. A corresponding procedure code must accompany a Z code if a procedure is performed. Categories Z00-Z99 are provided for occasions when circumstances other than a disease, injury or external cause classifiable to categories A00-Y89 are recorded as 'diagnoses' or 'problems'. This can arise in two main ways:
    • (a) When a person who may or may not be sick encounters the health services for some specific purpose, such as to receive limited care or service for a current condition, to donate an organ or tissue, to receive prophylactic vaccination (immunization), or to discuss a problem which is in itself not a disease or injury.
    • (b) When some circumstance or problem is present which influences the person's health status but is not in itself a current illness or injury.

More specific codes under Z16.2 6