Guidelines › Resistance to antimicrobial drugs (Z16)

Resistance to antimicrobial drugs (Z16)

Official text from the FY2027 ICD-10-CM Official Guidelines for Coding and Reporting. The wording is quoted exactly.

Guidelines I.C.1.c

“Assign a code from category Z16, Resistance to antimicrobial drugs, following the infection code only if the infection code does not identify drug resistance.”

Where this applies

19 billable codes. Source: FY 2027 ICD-10-CM Official Guidelines for Coding and Reporting, effective October 1, 2026. Full Guidelines (PDF, CMS)

The Guidelines are the authority for assigning codes, and following them is required under HIPAA. This page quotes them for convenience and is not a substitute for the official document. See the Terms and Disclaimer.